Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure
نویسندگان
چکیده
منابع مشابه
Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.
BACKGROUND AND OBJECTIVE Mutations in bone morphogenic protein 15 (BMP15) and growth/differentiation factor 9 (GDF9) lead to altered fertility in animal models. In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF). SUBJECT AND METHODS We have directly sequenced both genes in a cohort of 203 POF patients presenting with primary or second...
متن کاملBMP15 and GDF9 Gene Mutations in Premature Ovarian Failure
BACKGROUND Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. Mutations in bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been shown to be associated with POF. METHODS Genomic DNA was isolated from 52 idiopathic premat...
متن کاملbmp15 and gdf9 gene mutations in premature ovarian failure
background: premature ovarian failure (pof) is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. mutations in bone morphogenetic protein 15 (bmp15) and growth differentiation factor 9 (gdf9) have been shown to be associated with pof. methods: genomic dna was isolated from 52 idiopathic premat...
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چکیده ندارد.
I-36: The Necessity of Genetic Screening in Premature Ovarian Failure and Diminished Ovarian Reserved Patients
Variability in the subfertile patient population excludes the possibility of a single approach to controlled ovarian stimulation (COS) covering all the requirements of a patient. Modern medical science has made great advances in the understanding and the development of new drugs, treatment options and quantitative methods that can identify single patient characteristics. Factors that reduce fol...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2006
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.1.02135